When it hurts you just want relief from the pain.

GenVisc®850 and your doctor are here to help.

Genvisc for Knee Pain

What is GenVisc 850?

GenVisc 850 is a product that is injected into your knees to treat knee pain from joint inflammation and stiffness due to a disease known as osteoarthritis (OA).

GenVisc 850 is from a class of products known as hyaluronic acid, sodium hyaluronate, or hyaluronan (HA), which is also referred to as viscosupplementation therapy. It’s used in a nonsurgical procedure that helps supplement the viscous properties of the fluid in your knee joint. GenVisc 850 is approved for patients who have not adequately responded or have failed to find sufficient relief from simple analgesics, exercise or physical therapy.

How does GenVisc 850 work?

The fluid (synovial fluid) in your knee helps to lubricate and cushion the joint during movement. The major component in the synovial fluid is hyaluronic acid, the equivalent active component of GenVisc 850. One of the early effects of OA is to break down this fluid, making it less effective. It is thought that GenVisc 850 helps restore the synovial fluid to a more healthy state, thereby reducing the pain of OA.

How is GenVisc 850 administered?

GenVisc 850 is an intra-articular injection, which is injected into the space of the affected joint, between your thigh and calf bone.

How many injections should I receive?

GenVisc 850 is supported by the largest and longest duration double blinded clinical study of hyaluronic acids for knee osteoarthritis. Clinical studies demonstrated that five injections one week apart provide optimal pain relief. Some patients have derived benefits following the third injection. The effectiveness of less than three injections has not been evaluated.

When can I expect pain relief?

Each patient’s response to GenVisc 850 may vary. Depending on the severity of your OA, degree of pain, and pre-existing medical conditions. In some patients, successful treatment may reduce pain within the first week after treatment begins. However, based upon clinical trials, most patients experience pain relief after their third injection of GenVisc 850 given at weekly intervals.

You and your healthcare provider will decide upon the best course of treatment. Injection of subcutaneous lidocaine or similar local anesthetic may be recommended by your healthcare provider prior to injection of GenVisc 850. (See GenVisc 850 Patient Information)

How long can I expect the relief to last?

Each patient reacts differently to GenVisc 850 treatment. The benefits of GenVisc 850 can last for months. In clinical studies many patients experience 6 months or more pain relief. There are reports in the literature of pain relief beyond 6 months.

How safe is GenVisc 850?

GenVisc 850 is approved and has been determined to be safe and effective. It has also been used throughout the world over the past 20 years.† Now approved in 64 countries, with over 45 million syringes distributed worldwide.

What should I do after my treatments?

It is recommended that you avoid strenuous activities such as jogging, tennis, and heavy lifting for at least 48 hours after receiving an injection. Your healthcare provider will advise you about the level of activity that is right for you. Most patients are able to maintain their normal daily activities after receiving GenVisc 850 treatment.

Can I take other medications with GenVisc850?

Because GenVisc 850 is injected directly into the joint rather than administered systemically, and there are no known drug interactions, you may be able to take other medications with it. GenVisc 850 is not known to interfere with other pain relievers and anti-inflammatory drugs. The safety and effectiveness of the use of GenVisc 850 at the same time as other intra-articular injections, such as steroids, has not been established. Because it is administered locally it is unlikely that you will observe any benefit in joints not specifically injected. You should discuss all of your current medications and vitamin supplements with your physician on a periodic basis.

Are there any reasons why I should not receive GenVisc 850?

Avoid this product if you have a known hypersensitivity (allergy) to GenVisc 850 or HA products such as rash, itching, hives, flushing, swelling of the face, tongue or throat, and/or difficulty breathing.

Avoid in people with infections or skin diseases in the area of the injection site.

Please see the Full Prescribing Information.

What are the possible side effects?

Some side effects may occur during the use of GenVisc 850, with symptoms such as knee pain, inflammation, reddening, swelling appearing at the injection site and/or joint pain. Tell your healthcare provider if you experience any side effects after treatment of GenVisc 850.

Will my insurance cover GenVisc 850?

Most insurance carriers and Medicare cover GenVisc 850. The process of obtaining reimbursement varies from plan to plan so talk with your doctor’s office and your insurance provider before you begin treatment to find out if GenVisc 850 is covered.

How do I know if GenVisc 850 is right for me?

Your healthcare provider is the best person to advise you on any course of treatment. GenVisc 850 is approved for the treatment of knee pain due to Osteoarthritis of the knee in patients who do not get enough relief from simple over the counter pain medication or from exercise and physical therapy.

For more Information, please ask your healthcare provider or refer to the Full Prescribing Information for GenVisc 850.


Now approved in 64 countries with over 45 million syringes distributed worldwide.3 †

• Supported by data from the largest and longest duration double blind clinical study of hyaluronic acids for knee osteoarthritis.1
• Published in over 20 clinical studies. 2